Osteoarthritis has been linked to an increased risk of cardiovascular disease. Osteoarthritis presents a 42% increased risk of congestive heart failure, a 17% increased risk of coronary heart disease, and a 14% increased risk of stroke. A new study suggested 41% of the increased cardiovascular risk in osteoarthritis arises from the use of NSAIDs, such as ibuprofen (Advil or Motrin), naproxen (Aleve), and a variety of prescription NSAIDs.

The remaining increased risk arises from immortal pathogens, which are the root causes of osteoarthritis and cardiovascular disease.

Arthritis Tied to Heart Disease. Pain Relievers May Be to Blame.

Role of Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in the Association between Osteoarthritis and Cardiovascular Diseases: A Longitudinal Study

https://onlinelibrary.wiley.com/doi/10.1002/art.41027