Viral infections, chronic bacterial co-infections, parasites, environmental triggers, chemicals, and/or drugs are synergistic with chlamydia pathogens in triggering and exacerbating chronic disease. Studies in Africa, in areas where childhood cancer is endemic, identified endemic EBV (mononucleosis), in 100% of patients with Burkett’s lymphoma. Burkett’s lymphoma is also four times more common in men.

Most people are infected with EBV in their life; yet, not all patients with EBV develop Burkett’s lymphoma. EBV, HIV, and malaria are examples of co-morbid triggers, which act with chlamydia, in a patient who has impaired immunity, to trigger chronic disease and cancer.