Jack Blount, MD reported in Rheumatoid Diseases: Cured at Last, 1982, how difficult it was to watch the suffering around him, knowing he could help and he was unable to provide the help. We felt the same emotions watching suffering around us from chronic disease, knowing we could help but unable to provide the help.   While watching the suffering around us we also observed unprecedented success in Dr. Merchant’s patients with diseases without known causes and thought not treatable. Our vision for understanding chronic disease evolved over decades, based on experience, observation, research and discussion. Our desire to relieve suffering and longstanding rebel natures made it clear we had no choice but to write this book, to benefit others. It is time to move beyond rigidity and open minds to new ways of thinking in medicine and in medical research.