Historically, soldiers who were given anti-malaria medications noticed their rheumatoid arthritis and lupus symptoms improved. The effectiveness of anti-malaria drugs against rheumatoid arthritis and lupus supports the underlying cause is an immortal bacteria and/or parasite, which can be treated with anti-malaria medication. Knowing anti-malaria medications improve theses chronic diseases, should direct research to find which pathogens among those treated by anti-malaria drugs are causing these chronic diseases. Success in treatment should direct research to find causes.