The scientific evidence is mounting—chlamydia species cause neurodegenerative diseases.  Chlamydia pneumonia has repeatedly been linked to Alzheimer’s disease; and chlamydia pneumonia is known to generate beta-amyloid plaque, such as found in Alzheimer’s brains.  Chlamydia trachoma has been linked to Parkinson’s disease; and chlamydia trachoma generates excess alpha-synuclein proteins, which is found in Parkinson’s disease. Chlamydia pneumonia and trachoma also generate inclusion cysts and protein aggregates, which are found in Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases.

Many chlamydia species are yet to be investigated; and hundreds more likely exist, and could play a role in neurodegenerative and other chronic diseases. Expanding research, to include more sophisticated and expanded testing for immortal pathogens; expanded patient testing; and determination of the most effective treatment for these pathogens, could lead to new discoveries.  Understanding the time from acute infection to chronic disease, and what early treatment is beneficial, could also lead to important discoveries, in many chronic diseases.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189393/  (chlamydia pneumonia in Alzheimer’s);
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039821/ (chlamydia pneumonia generates beta-amyloid similar to Alzheimer’s);
3. https://www.sciencedirect.com/science/article/pii/S0014488608001520 (Parkinson patient fibroblasts show increased alpha-synuclein expression);
4. mbio.asm.org/content/10/2/e00225-19.abstract  (ocular and sexually trachoma generates fibroblasts and alpha-synuclein).